Coronaviruses, especially SARS CoV-2 has caused over 2.5 million deaths in the world in 2020-2021 during the COVID-19 pandemic uptill now. With several new mutants of this virus emerging, there is a need for a better understanding of the biology of viral fusion and entry into the host cells. Therefore, my project will be focussed on understanding the coronavirus spike protein, which mediates viral entry into cells. I will be investigating changes in fusion as well as infectivity caused by mutations in a specific region of this spike protein known as the fusion peptide. We hope to leverage biophysics techniques and provide insight into molecular level fusion interactions that will ultimately inform the creation of better therapeutics and antiviral drugs that target fusion.