Chemical and Biomolecular Engineering
- National Science Foundation Fellow
- NSF GRFP recipient
- Sloan Fellowship recipient
I study the dynamic Interactions between oncogenic extracellular vesicles and adipose stem cells. Extracellular vesicles derived from breast cancer cells are known to play an important role in cancer tumorigenesis and metastasis. However, it is not well understood how extracellular vesicles interact with healthy cells leading to cell transformation, angiogenesis, and cancer progression. Therefore, I aim to study the dynamic interactions happening at the surface of adipose stem cells and oncogenic extracellular vesicles leading to malignant biological outcomes. To do so, I created extracellular vesicles derived supported bilayers as a cell culture platform to understand the interactions between adipose stem cells and the surface of extracellular vesicles. In the same manner, I use adipose stem cells derived supported bilayers and isolated extracellular vesicles to study the interactions leading to entrance and cargo delivery of extracellular vesicles in stem cells. Such interactions are investigated using techniques as FRAP, TIRFM, and Single Particle Tracking (SPT). The goals of my research are to uncover and explain the nature of these interactions.
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