I elucidate interactions between bacteria membrane and antibiotics using OM-SB platform. More specifically, my work involves developing a platform to study the outer membranes of bacteria in hopes of uncovering their role in antibiotic resistance. To do this, I isolate outer membrane vesicles (OMVs) and use them to form supported bilayers that we can quantitatively characterize and study using tools such as Fluorescence Recovery After Photobleaching (FRAP) and Quartz Crystal Microbalance with Dissipation (QCM-D). As the bacteria membrane is the first barrier for antibiotics, understanding the interactions between bacteria membrane and antibiotics is fundamental for developing the next generation of antibiotics.
- Brown J, Mohamed Z, et al. Antibacterial isoamphipathicoligomers highlight the importance of multimeric lipid aggregation for antibacterial potency. Communications Biology. 2018, 1(220)
- Townsley S, Mohamed Z, et al. Induction of heterologous Tier 2 HIV-1 neutralizing and cross-reactive V1/V2-specific antibodies in rabbits by prime-boost immunization. Journal of Virology. 2016, 90(19):8644-60.
- Mohamed Z, King MR. Dualnanoparticledrug delivery: the future of anti-cancer therapies. Nanomedicine. 2016, 12(2): 95-98.